André B P van Kuilenburg Selected Research

BL1521

2/2006	Antagonistic effects of sequential administration of BL1521, a histone deacetylase inhibitor, and gemcitabine to neuroblastoma cells.
10/2005	Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma.
2/2005	Histone deacetylase inhibitor BL1521 induces a G1-phase arrest in neuroblastoma cells through altered expression of cell cycle proteins.
10/2004	The novel histone deacetylase inhibitor BL1521 inhibits proliferation and induces apoptosis in neuroblastoma cells.

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André B P van Kuilenburg Research Topics

Disease

21	Neoplasms (Cancer) 01/2022 - 05/2002
19	Dihydropyrimidine Dehydrogenase Deficiency 01/2022 - 05/2002
14	Neuroblastoma 01/2022 - 09/2002
6	Fabry Disease (Fabry's Disease) 08/2020 - 01/2017
5	Inflammation (Inflammations) 01/2022 - 10/2012
3	Intellectual Disability (Idiocy) 01/2019 - 07/2012
3	Pneumonia (Pneumonitis) 01/2013 - 06/2008
2	Thrombocytopenia (Thrombopenia) 08/2021 - 07/2020
2	Arts syndrome 03/2021 - 02/2014
2	Disease Progression 01/2020 - 01/2017
2	Fibrosis (Cirrhosis) 01/2020 - 01/2017
2	Ataxia (Dyssynergia) 11/2019 - 01/2015
2	Seizures (Absence Seizure) 01/2019 - 07/2012
2	Cholestasis 03/2018 - 10/2012
2	Dihydropyrimidinase Deficiency 12/2017 - 10/2003
2	Neoplasm Metastasis (Metastasis) 01/2017 - 07/2015
2	Ischemia 01/2017 - 10/2012
2	Infections 06/2008 - 12/2003
2	Neutropenia 06/2008 - 01/2007
1	Atopic Dermatitis (Atopic Eczema) 01/2022
1	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 10/2020
1	Niemann-Pick Diseases (Niemann Pick Disease) 01/2020
1	Pulmonary Arterial Hypertension 01/2020
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020
1	Type B Niemann-Pick Disease 04/2019
1	Fever (Fevers) 01/2019
1	Language Development Disorders (Semantic-Pragmatic Disorder) 01/2019
1	Acidosis 01/2019
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 01/2019
1	Cognitive Dysfunction 01/2019
1	Psychotic Disorders (Schizoaffective Disorder) 01/2019

Drug/Important Bio-Agent (IBA)

15	Fluorouracil (Carac)FDA LinkGeneric 01/2021 - 05/2002
14	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 01/2021 - 05/2002
7	pyrimidineIBA 01/2019 - 07/2003
6	Capecitabine (Xeloda)FDA Link 01/2021 - 06/2008
6	EnzymesIBA 01/2021 - 03/2012
5	Pharmaceutical PreparationsIBA 01/2021 - 01/2006
4	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2011
4	UracilIBA 01/2022 - 12/2011
4	Gemcitabine FDA Link 01/2016 - 01/2006
4	BL1521IBA 02/2006 - 10/2004
4	Histone Deacetylase InhibitorsIBA 02/2006 - 10/2004
3	LipidsIBA 01/2022 - 11/2016
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2019
3	CatecholaminesIBA 01/2022 - 11/2016
3	ThymineIBA 01/2019 - 05/2002
2	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 11/2016
2	CytokinesIBA 01/2022 - 08/2010
2	3-Iodobenzylguanidine (Iobenguane)IBA 08/2021 - 07/2020
2	Citalopram FDA LinkGeneric 08/2021 - 07/2020
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 08/2021 - 07/2020
2	Therapeutic UsesIBA 08/2021 - 07/2020
2	agalsidase alfaIBA 08/2020 - 01/2018
2	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 01/2020 - 08/2010
2	SphingomyelinsIBA 01/2020 - 04/2019
2	AcidsIBA 04/2019 - 07/2012
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 02/2006
2	UridineIBA 01/2019 - 01/2016
2	ProdrugsIBA 01/2018 - 08/2010
2	CytidineIBA 01/2016 - 09/2002
2	dihydrouracilIBA 07/2015 - 12/2011
2	Ligases (Synthetase)IBA 02/2014 - 09/2002
2	NucleotidesIBA 10/2012 - 12/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2011 - 03/2010
2	FenretinideIBA 09/2011 - 03/2010
2	Azathioprine (Imuran)FDA LinkGeneric 08/2010 - 06/2008
2	phytobacteriomycin (PBM)IBA 01/2007 - 01/2003
2	CTP synthetaseIBA 01/2006 - 09/2002
2	cyclopentenyl cytosineIBA 01/2006 - 09/2002
2	Histone Deacetylases (Histone Deacetylase)IBA 10/2005 - 10/2004
1	3-methoxytyramine (methoxytyramine)IBA 01/2022
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2022
1	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022
1	S-Adenosylmethionine (Ademetionine)IBA 03/2021
1	nicotinamide-beta-ribosideIBA 03/2021
1	Sulfoglycosphingolipids (Sulfatides)IBA 10/2020
1	Cerebroside-Sulfatase (Arylsulfatase A)IBA 10/2020
1	AntibodiesIBA 08/2020
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 07/2020
1	Paroxetine (Paxil)FDA LinkGeneric 07/2020
1	Fluvoxamine (Luvox)FDA LinkGeneric 07/2020
1	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 07/2020
1	Sertraline (Zoloft)FDA LinkGeneric 07/2020
1	LDL CholesterolIBA 01/2020
1	migalastatIBA 01/2020
1	GalactosidasesIBA 01/2020
1	sphingosine phosphorylcholineIBA 01/2020
1	Glutamine (L-Glutamine)FDA Link 11/2019
1	CeramidesIBA 04/2019
1	Phosphorylcholine (Phosphocholine)IBA 04/2019
1	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 04/2019
1	Dopa DecarboxylaseIBA 01/2019
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2019
1	Antipsychotic Agents (Antipsychotics)IBA 01/2019
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 03/2018

Therapy/Procedure

10	Therapeutics 08/2021 - 07/2003
5	Enzyme Replacement Therapy 01/2020 - 01/2017
5	Drug Therapy (Chemotherapy) 01/2018 - 01/2003
2	Drug Tapering 01/2018 - 10/2016
1	Radiotherapy 11/2018